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 Cholesterol Lowering Statins Found To Damage Peripheral Nerves

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Posts : 7992
Join date : 2012-05-29
Location : Manchester UK

PostSubject: Cholesterol Lowering Statins Found To Damage Peripheral Nerves   Fri 16 Nov 2012, 17:22

Cholesterol Lowering Statins Found To Damage Peripheral Nerves

Have the nerve-damaging properties of statin drugs now been confirmed?
There are over 300 adverse health effects associated with the use of
this chemical class of cholesterol-lowering medications known as
statins, with myotoxicity (muscle-damaging) and neurotoxicity
(nerve-damaging) top on the list.

When will the FDA step in and warn the public, as proof of the problem
in the biomedical literature reaches an alarming level of clarity?

The neurotoxicity of statin drugs are back in the news. Following on the
heels of the FDA decision earlier this year to require statin drugs
manufacturers to add "memory loss" as a side effect of this chemical class, a new study in published in the Journal of Diabetes reveals a clear association between statin use and peripheral neuropathy in a US population 40 years of age and older.

The study found "The prevalence of peripheral neuropathy was
significantly higher among those who used statins compared to those who
did not (23.5% vs. 13.5%; p < 0.01)," which is a 75% increase in
relative risk.

Case reports of statin-induced peripheral neuropathy have existed in the medical literature for over 15 years.
Now, larger human studies are confirming that statin drugs do damage to
the peripheral nerves. Moreover, much of the damage is occurring below
the threshold of clinical surveillance, silently causing harm in
unsuspecting patients.

For example, in 2011, the results of a 36-month prospective clinical and
neurophysiological follow-up of patients treated with statins over 3
years was published in the journal [i]Neuro Endocrinology Letters
revealed in forty-two patients that despite the fact that they did not
report subjective symptoms typical for peripheral neuropathy, damage was
occurring.[ii] They concluded:
<blockquote class="tr_bq">
The study confirmed that long-term treatment with statins caused a
clinically silent but still definite damage to peripheral nerves when
the treatment lasts longer than 2 years.</blockquote>
Click the hyperlink to view all 9 studies on statin-induced peripheral neuropathy on Or, view an even more sizeable dataset (54 studies) on statin-associated neurotoxicity.

While this research is adding to a growing awareness of the
nerve-damaging properties of statins, this side effect is just the tip
of a massive iceberg of under reported deleterious effects. For example,
our project has identified 314 possible adverse effects of statins thus far. Conversely, we have identified a wide range of health benefits of cholesterol, running diametrically opposed to the over-simplification inherent in the cholesterol hypothesis (some say "cholesterol myth") of heart disease causation.

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