Vaccines for Deadly Malaria Create Even More Virulent Malaria

Vaccines for Deadly Malaria Create Even More Virulent Malaria: PLoS Study



The risk to all of us in a malaria vaccine, whether we
vaccinate or not, is enormous. This study demonstrates that a more
virulent and deadly form of malaria is a near-certain outcome.


Blood-filled Anopheles Mosquito


by Heidi Stevenson

Malaria is a killer. Obviously, the last thing we need is a more
virulent malaria. Yet, that is precisely what the malaria vaccine will
probably cause. A study published by PLoS Biology found that “virulence evolved” through malaria vaccinations.

Malaria is a disease that causes severe chills, fevers, sweats, fatigue, and anemia. It’s caused by Plasmodium parasites,
which are carried by the Anopheles mosquito. It’s transmitted through
the mosquito’s “bite” when it feeds. Unlike other diseases, its symptoms
have a nasty tendency to return, often years after initial infection.

For people in the northern hemisphere, malaria hasn’t been much of a
problem, but with climate change’s warming, the malaria-carrying
mosquitoes have moved further north and now pose risks to North America
and Europe.

This, of course, means that an enormous new profit center is
developing for malaria vaccines. Therefore, there’s been a burst of
research to develop them. Of course, such research is focused on one
thing: bringing a product to market. Concerns about the long term
effects are not addressed by vaccine researchers. Fortunately, though,
one team of scientists has investigated the potential risk of such a
vaccine. The findings should give pause to the gung-ho vaccine
developers—but almost certainly won’t.

Genetically Engineered Vaccine Concerns


Most research into new vaccines tends to utilize recombinant DNA
technology. That is, they are creating genetically modified organisms to
make vaccines. These vaccines are generally created by implanting a
gene that causes a plant to make a molecule that becomes an antigen in a
vaccine. These antigens are bits of proteins, which are called epitopes
when antibodies are created against them.

According to the study, several vaccine-created epitopes are known to
evolve, resulting in ineffective or less effective vaccines. Specific
diseases referenced include the hepatitis B virus, Bortadella pertussis (whooping cough), and Streptococcus pneumoniae.

Although the evolution of epitopes is a concern with some
vaccines, there is another, even more serious worry. The possibility of
vaccinations causing the evolution of the infectious agents themselves was the focus of this study. As the authors state:

<blockquote>Vaccination could favor virulent malaria parasites in two
ways. First, [point 1] if the primary force preventing the evolution of
more virulent strains is that they kill their hosts and therefore
truncate their infectious periods, keeping hosts alive with vaccination
will allow more virulent strains to circulate. Second, [point 2]
immunity might be less effective against virulent strains. ["Point 1"
and "point 2" added by me.]
</blockquote>
Their first point is that vaccines may result in more virulent forms
of a disease by removing it from the pool of variants, which can result
in their place being taken by a more virulent disease. As discussed in Whooping Cough Epidemic Caused by Virulent New Pertussis Strain—And It’s the Result of Vaccine, this has been known to happen in the case of pertussis, and is behind much of the current whooping cough outbreaks.

The second point of concern is simply that the vaccines may not be as
effective against more virulent strains. This point is already an
issue, as in the case of the vaccine-induced more virulent strain of
pertussis.

Leaky Vaccines


Further complicating the issue is that any malaria vaccine is
“leaky”. The term leaky refers to a vaccine that does not kill all of an
individual’s disease-causing agents. This study documented that malaria
vaccines are, indeed, leaky.

The risk is that infections of evolved organisms can be spread from
one individual to another through mosquitoes. If a person with an
evolved and more virulent Plasmodium parasite is bitten by a
mosquito, it can be transmitted to other people. The mosquito has become
a carrier of the newly evolved Plasmodium parasite.

This study found that more severe symptoms developed in mice after Plasmodium had been passed through only ten individual mice through leaking.

RedOrbit reports lead author Andrew F. Read as saying:

<blockquote>Leaky vaccines create a situation that further fosters
parasite evolution. The parasites that are able to survive in the
immunized hosts must be stronger after having survived exposure to the
vaccine. The vaccine-induced immunity apparently removed the less
virulent malaria parasites, but left the more virulent ones.
</blockquote>
RedOrbit also quotes Victoria Barclay, who conducted the laboratory experiment:

<blockquote>We were surprised to find that more-virulent strains of
malaria evolved even while the gene encoding the key antigen remained
unchanged. We did not detect any changes in the gene sequence.
</blockquote>
The Inherent Danger to All of Us


Read says that ongoing monitoring needs to be done to see if a
malaria vaccine causes more virulent strains of malaria. But frankly,
that simply isn’t good enough. By the time any monitoring system
discovers that an already deadly disease has evolved to become even more
virulent, it’s too late. The new, more deadly strain, is already out
there.

Though the authors leave the impression that the vaccines will likely
continue to protect against these more virulent diseases, the reality
is that they don’t know it. We already know that the slightest variance
in an influenza virus results in a new disease unaffected by existing
vaccines.

The fact is that scientists, medical doctors, and health agencies are
playing games with our lives. At some point, an untreatable and
unstoppable disease is almost certain to arise as a direct result of the
vaccines being pushed. In the case of malaria, we’re already dealing
with a particularly nasty disease, one that causes tremendous misery and
death. How much of a mutation is required for it to become an
uncontrollable pandemic?

We don’t know. But that doesn’t stop them. Nothing seems to even slow the profit-making vaccination juggernaut.




Source:-
http://gaia-health.com/gaia-blog/2012-08-02/vaccines-for-deadly-malaria-create-even-more-virulent-malaria-plos-study/